GORD Pathophysiology

Please sign in to your myUEG account to begin this course now

The diagnosis and treatment of gastro-oesophageal reflux disease (GORD) have been driven by our knowledge of its pathophysiology. From equating GORD with oesophagitis and hiatal hernia to identifying the role of transient lower oesophageal sphincter relaxations, different GORD phenotypes and microscopic features, the pathophysiology is now understood to be multifactorial.

This online course covers the different components that contribute to the pathophysiology of GORD by following the path of the refluxate. The role of the stomach, antireflux barrier, refluxate, clearance mechanisms, mucosa and symptom perception are each considered in turn.  

The course includes comprehensive PPT slides and video footage. The combined material has a total duration of approximately 70 minutes. The estimated time needed to complete the course, including the final assessment, is 1 hour 20 minutes.

This course was developed by: UEG.

  • To understand that the pathophysiology of GORD is multifactorial
  • To become familiar with each of the individual pathophysiology abnormalities
  • To realize that patients with different GORD phenotypes may have different underlying pathophysiological mechanisms
  • To recognize that treatment of GORD should be designed to modify the specific pathophysiology
  • To appreciate that patients with GORD who have similar symptoms but different pathophysiology mechanisms may need different treatments


Daniel Sifrim, Professor of GI Physiology, Wingate Institute of Neurogastroenterology, QMUL, London, UK, and Director of Upper GI Physiology Unit, Royal London Hospital, London, UK. 

Kornilia Nikaki, Clinical Research Fellow, Wingate Institute of Neurogastroenterology, QMUL, London, UK.

Manuele Furnari, Assistant Professor of Gastroenterology, Department of Internal Medicine, Gastroenterology Unit, Policlinico San Martino- IRCCS, University of Genoa, Genoa, Italy.

  • The course is designed to last approximately 1 hour 20 minutes in total. 
  • The author and the course editor have declared that they have no conflicts of interest in relation to the material in this course. 
  • The production of this course was funded entirely by UEG. No external sponsorship was received.
  • The material used in this course was prepared in 2018.
  • Unless otherwise stated, display items are provided courtesy of the course authors.
  • Learners are invited to test their knowledge at the beginning and the end of the course via a series of 10 MCQs.
  • The course has a pass mark of 70%. Those scoring less than the required pass mark are encouraged to revisit the course and retake the assessment.

Release Date: October 2018

            This course, made available on www.ueg.eu and organised by United European Gastroenterology, is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to award 1 European CME credit (ECMEC).
            Each medical specialist should claim only those credits that he/she actually spent in the educational activity. The EACCME is an institution of the European Union of Medical Specialists (UEMS). Only those e-learning materials that are displayed on the UEMS-EACCME website have formally been accredited.