EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis

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Liver fibrosis is part of the structural and functional alterations in most chronic liver diseases. It is one of the main prognostic factors as the amount of fibrosis is correlated with the risk of developing cirrhosis and liver-related complications in viral and non-viral chronic liver diseases. Liver biopsy has traditionally been considered the reference method for evaluation of tissue damage such as hepatic fibrosis in patients with chronic liver disease. Pathologists have proposed robust scoring system for staging liver fibrosis such as the semi-quantitative METAVIR score. 

Keywords: chronic liver disease; liver cirrhosis; liver fibrosis; chronic hepatitis C; radiation force impulse; nonalcoholic fatty liver; transient elastography fibroscan; primary biliary cirrhosis; virus-coinfected patients; large oesophageal varices; hepatocellular-carcinoma development; magnetic resonance elastography; significant portal hypertension

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Publishing organization(s):

EASL European Association for the Study of the Liver, Asociacion Latinoamericana para el Estudio del Higado (ALEH)

Scientific area:


This item can be cited as:  Journal of Hepatology 2015 vol. 63 j 237–264; PMID 25911335


  • Format
    • Standards and Guidelines
  • Language
    • English
  • UEG Member Society
    • European Association for the Study of the Liver (EASL)
  • UEG Week Pathway
    • Hepatobiliary
  • Year
    • 2015