Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract - Recommendations of Verona Consensus Meeting


There are no established guidelines for pathologic diagnosis/ reporting of intraductal papillary mucinous neoplasms (IPMNs). 

An international multidisciplinary group, brought together by the Verona Pancreas Group in Italy–2013, was tasked to devise recommendations.

(1) Crucial to rule out invasive carcinoma with extensive (if not complete) sampling.
(2) Invasive component is to be documented in a full synoptic report including its size, type, grade, and stage. 
(3) The term ‘‘minimally invasive’’ should be avoided; instead, invasion size with stage and substaging of T1 (1a, b, c; 0.5, >0.5–1, >1 cm) is to be documented.
(4) Largest diameter of the invasion, not the distance from the nearest duct, is to be used.
(5) A category of ‘‘indeterminate/(suspicious) for invasion’’ is acceptable for rare cases.
(6) The term ‘‘malignant’’ IPMN should be avoided.
(7) The highest grade of dysplasia in the non-invasive component is to be documented separately.
(8) Lesion size is to be correlated with imaging findings in cysts with rupture.
(9) The main duct diameter and, if possible, its involvement are to be documented; however, it is not required to provide main versus branch duct classification in the resected tumor.
(10) Subtyping as gastric/intestinal/pancreatobiliary/oncocytic/mixed is of value.
(11) Frozen section is to be performed highly selectively, with appreciation of its shortcomings.
(12) These principles also apply to other similar tumoral intraepithelial neoplasms (mucinous cystic neoplasms, intra-ampullary, and intrabiliary/cholecystic). 

These recommendations will ensure proper communication of salient tumor characteristics to the management teams, accurate comparison of data between analyses, and development of more effective management algorithms.

Keywords: fine-needle aspiration; multifocal/multicentric breast-carcinoma; important prognostic-factor; invasive ductal carcinoma; lymph node metastasis; long-term survival; clinicopathological features; cystic neoplasms; margin status; extrapancreatic malignancies

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Source File

Publishing organization(s):

Members of the Verona Consensus Meeting, 2013

Scientific area:

Pancreas, Surgery

This item can be cited as: Ann Surg 2016;263:162–177; PMID 25775066


  • Format
    • Standards and Guidelines
  • Language
    • English
  • UEG Week Pathway
    • Digestive Oncology
    • Histopathology
    • Pancreas
    • Surgery
  • Year
    • 2016